Evidence of vaccine-related reassortment of rotavirus, Brazil, 2008-2010

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Abstract

Analysis of 27 rotavirus strains from vaccinated and unvaccinated children revealed reassortment events in 3 strains: a gene derived from a vaccine; a gene acquired from a circulating strain; and reassortment between circulating strains. Data suggest that the widespread use of this monovalent rotavirus vaccine may introduce vaccine genes into circulating human rotaviruses or vice versa.

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Rose, T. L., da Silva, M. F. M., Goméz, M. M., Resque, H. R., Ichihara, M. Y. T., Volotão, E. de M., & Leite, J. P. G. (2013). Evidence of vaccine-related reassortment of rotavirus, Brazil, 2008-2010. Emerging Infectious Diseases, 19(11), 1843–1846. https://doi.org/10.3201/eid1911.121407

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