Srivastava et al. used unbiased PCNA-centered approaches to construct landscapes of replisome complexes with or without replication stress. These findings uncover many known and previously unexplored proteins that are potentially important for the resolution of two different types of replication fork-blocking lesions.
Srivastava, M., Chen, Z., Zhang, H., Tang, M., Wang, C., Jung, S. Y., & Chen, J. (2018). Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome. Cell Reports, 25(13), 3869-3883.e4. https://doi.org/10.1016/j.celrep.2018.11.099