An integrated map of HIV-human protein complexes that facilitate viral infection

12Citations
Citations of this article
47Readers
Mendeley users who have this article in their library.

Abstract

Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human interaction network provides invaluable information as to how HIV exploits the host machinery and can be used as a starting point for further functional analyses. We integrated this network with complementary datasets of protein function and interaction to nominate human protein complexes with likely roles in viral infection. Based on our approach we identified a global map of 40 HIV-human protein complexes with putative roles in HIV infection, some of which are involved in DNA replication and repair, transcription, translation, and cytoskeletal regulation. Targeted RNAi screens were used to validate several proteins and complexes for functional impact on viral infection. Thus, our HIV-human protein complex map provides a significant resource of potential HIV-host interactions for further study. © 2014 Emig-Agius et al.

Cite

CITATION STYLE

APA

Emig-Agius, D., Olivieri, K., Pache, L., Shih, H. L., Pustovalova, O., Bessarabova, M., … Ideker, T. (2014). An integrated map of HIV-human protein complexes that facilitate viral infection. PLoS ONE, 9(5). https://doi.org/10.1371/journal.pone.0096687

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free