Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass

  • Baeg M
  • Choi M
  • Ko S
  • et al.
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? 2015 Baeg et al.Background: Sarcopenia is associated with adverse outcomes such as physical disability, poorer quality of life, and death. Helicobacter pylori (HP) eradication increases ghrelin secretion, which may be a possible treatment for sarcopenia. We investigated whether HP eradication reduces the risk of low muscle mass (LMM), which is an integral component of sarcopenia. Materials and methods: Healthy, asymptomatic women aged $60 years who participated in a health screening program were enrolled. Subjects with a history of HP eradication were compared with those who were HP IgG+, but had not received HP-eradicating therapy. Body composition was measured by multifrequency bioelectrical impedance analysis. LMM was defined as body muscle mass 2 standard deviations below the mean muscle mass of healthy women aged 20-39 years from the same program. Multivariable analysis was used to identify sarcopenia risk factors. Results: Three hundred seventy-two women had received HP eradication, while 689 HP IgG+women had not. The prevalence of LMM was significantly lower in those who received HP eradication (13.7% vs 21.6%, P=0.002). Multivariable analysis identified risk factors for LMM as age, white blood cell count, serum total protein concentration, and the metabolic syndrome. HP eradication (odds ratio: 0.632, 95% confidence interval: 0.440?0.824, P=0.013) was a significant preventive factor, and exercise (odds ratio: 0.710, 95% confidence interval: 0.504?1.002, P=0.051) had a preventive tendency. Conclusion: HP eradication might reduce LMM risk. This finding should be confirmed in prospective longitudinal studies to determine the long-term effects of HP eradication on sarcopenia.




Baeg, M. K., Choi, M.-G., Ko, S.-H., Lim, C.-H., Kim, J. S., Cho, Y. K., … Lee, I.-S. (2015). Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass. Clinical Interventions in Aging, 1771. https://doi.org/10.2147/cia.s95007

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