Chemoreversal metabolites from the endophytic fungus penicillium citrinum isolated from a mangrove avicennia marina

Abstract

Two new compounds, named (Z)-7,4′-dimethoxy-6-hydroxyaurone-4-O-β]-glucopyranoside (1) and (α)-4-O-(4-O-β]-D-glucopyranosylcaffeoyl)quinic acid (2), were isolated from the endophytic fungus Penicillium citrinum of Avicennia marina. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compound 2 exhibited potent chemoreversal activity, mainly by inhibiting P-glycoprotein efflux pump function.