Analgesic effects of Neurotropin in mice, and comparison between analgesic effects of some drugs in SART-stress mice and normal mice

Abstract

Analgesic effects of a neuroleptica °Neurotropin ± (NSP) were studied in mice while the analgesic effects of other agents were studied in SART-stress mice (specific stress caused by alterating rhythm in temperature) and the results compared with those in normal mice. NSP is an extract containing many conjugated polysacca-rides isolated from the skin or tissues of rabbits which had been inoculated with the living cowpox virus, (a) NSP given alone to normal mice resulted in slight analgesic effects as observed with the application of the acetic acid-, phenylquinon-writhing method or the modified Randall-Selitto method. IJttle effect was seen when the D'Amour-Smith method was used, (b) Synergism was evident when NSP and aminopyrine or NSP and morphine were given concomitantly and the acetic acid- or phenylquinon-writhing methods were applied, (c) Analgesic effects of morphine, levomepromazine, imidazole acetic acid and particularly NSP were greater in SART-stress mice than in normal mice. With the D'Amour-Smith method, only NSP had a greater effect in SART-stress mice than in normal mice. © 1976, The Japanese Pharmacological Society. All rights reserved.