Living radical polymerization as a tool for the synthesis of polymer-protein/peptide bioconjugates

Abstract

Combinations of synthetic and natural macromolecules offer a route to new functional materials. While biological and polymer chemistry may not be natural bedfellows, many researchers are focusing their attention on the benefits of combining these fields. Recent advances in living radical polymerization have provided methods to build tailor-made macromolecular moieties using relatively simple processes. This has led to a plethora of block copolymers, end-functional polymers and polymers with a whole range of biological recognition abilities. This review covers work carried out until late 2006 combining living radical polymerization with proteins and peptides in the rapidlyexpanding field of bioconjugation. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.