Hematobiochemical changes of lead poisoning and amelioration with ocimum sanctum in wistar albino rats

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Abstract

An experiment was carried out to study the hematobiochemical changes of chronic lead poisoning in adult male wistar albino rats for a period of twelve weeks. Adult 216 healthy rats were randomly divided into six groups viz. control (groupI), higher dose of lead acetate @60mgs/kg bwt (group II), Lower dose of lead acetate @ 30 mgs / kg bwt (group III), Higher dose of lead + Ocimum @ 400 mgs/ kg bwt (group IV), lower dose of lead + Ocimum@ 400 mgs/ kg bwt (group V), Ocimum control (group VI). All lead treated and ameliorated groups given Lead acetate/ lead + Ocimum orally for three days in a week for a period of twelve weeks. The mean PCV, Hb, values were reduced significantly (P<0.05) in lead treated rats as dose dependent manner. Where as significant improvement was noticed in Ocimum treated groups Increased TLC and PLC values as dose dependent manner. A significant reduction in PNC was noticed in ocimum treated groups. Significant (P<0.05) decrease in serum total protein values, serum glucose and increased creatinine values were observed in lead treated groups as dose dependent. Increased protein & glucose and decreased creatinine values obtained in Ocimum treated groups. The alterations in hematological and biochemical parameters in the present study indicates decreased lifespan & fragility of RBC and damage to liver, kidney and Pancreas in lead poisoned wistar albino rats.

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Karamala, S. K., Sri latha, C., Anjaneyulu, Y., Chandra Sekhara Rao, T. S., Vasulu, D. S., & Pidugu, A. P. (2011). Hematobiochemical changes of lead poisoning and amelioration with ocimum sanctum in wistar albino rats. Veterinary World, 4(6), 260–263. https://doi.org/10.5455/vetworld.4.260

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