Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
Cohen, I., Navarro, V., Le Duigou, C., & Miles, R. (2003). Mesial temporal lobe epilepsy: A pathological replay of developmental mechanism? Biology of the Cell, 95(6), 329–333. https://doi.org/10.1016/S0248-4900(03)00081-9