A case of multilocular cystic hepatocellular carcinoma without underlying cirrhosis

Abstract

A 52-year-old woman was admitted to our hospital because of marked hepatomegaly. The findings of Ultrasound, CT scan and Angiography suggested a hepatocellular carcinoma (HCC) associated with multiple cysts. The open biopsy was performed to confirm the diagnosis. A huge massive tumor about 10 cm in diameter partially associated with multiple cystic lesions was observed in the right lobe of liver at laparotomy. The histological finding of the tumor was HCC, and the nontumorous part was almost normal liver. TAE, intraarterial administration of 5-FU and CDDP, and oral administration of UFT were performed, resulting in the improvement of hepatomegaly (reduction rate: 63.8%, partial response). The marked reduction of the tumor and cystic lesions was shown using CT scan. It is characteristic in this case that HCC developed in the normal liver and was associated with multiple cystic lesions. This case seems to be interesting from the viewpoint of the pathogenesis of multicystic HCC and the therapeutic effect of TAE and chemotherapy. © 1989, The Japan Society of Hepatology. All rights reserved.