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TFIID Enables RNA Polymerase II Promoter-Proximal Pausing

Molecular Cell (2020) 78(4) 785-793.e8
DOI: 10.1016/j.molcel.2020.03.008
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Abstract

Fant and co-workers use biochemical reconstitution to discover that the general transcription factor TFIID is required to establish RNAPII promoter-proximal pausing; canonical regulatory factors NELF and DSIF enhance pausing but are not required. Follow-up experiments in human and Drosophila cells show TFIID is a conserved regulator of RNAPII pausing.

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Fant, C. B., Levandowski, C. B., Gupta, K., Maas, Z. L., Moir, J., Rubin, J. D., … Taatjes, D. J. (2020). TFIID Enables RNA Polymerase II Promoter-Proximal Pausing. Molecular Cell, 78(4), 785-793.e8. https://doi.org/10.1016/j.molcel.2020.03.008

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