Objective: To evaluate the efficacy of superovulation and IUI versus no treatment for infertility associated with minimal or mild endometriosis. Design: Randomized trial. Setting(s): London Health Sciences Centre, University Campus, The University of Western Ontario, London, Ontario; and Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada. Patient(s): Three hundred eleven cycles in 103 couples in whom minimal or mild endometriosis was the sole identified subfertility factor. Intervention(s): Superovulation with FSH and IUI. Main Outcome Measure(s): Live birth. Result(s): Live birth followed 14 of 127 (11%) superovulation and IUI cycles and 4 of 184 (2%) no-treatment cycles. The odds ratio was 5.6 (95% confidence interval 1.8 to 17.4) in favor of superovulation and IUI. Conclusion(s): Treatment with superovulation and IUI was associated with superior outcome both by crude live-birth rates and proportional hazard analysis.
Tummon, I. S., Asher, L. J., Martin, J. S. B., & Tulandi, T. (1997). Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. Fertility and Sterility, 68(1), 8–12. https://doi.org/10.1016/S0015-0282(97)81467-7