Argonaute proteins are the mediators of small RNA-guided gene silencing pathways. In this issue, Couvillion and coworkers (Couvillion et al., 2012) found an unexpected function for a Tetrahymena Argonaute protein: It forms a complex with tRNA fragments and is required for nuclear Xrn2 localization and function. © 2012 Elsevier Inc.
Hasler, D., & Meister, G. (2012, November 30). An Argonaute Protein Directs Nuclear Xrn2 Function. Molecular Cell. https://doi.org/10.1016/j.molcel.2012.11.015