Natural IgE production in the absence of MHC class II cognate help

82Citations
Citations of this article
84Readers
Mendeley users who have this article in their library.

Abstract

IgE induction by parasites and allergens is antigen driven and cognate T cell help dependent. We demonstrate that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help. This does not require secondary lymphoid structures or germinal center formation, although some bystander T cell-derived IL-4 is necessary. The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals. ©2006 Elsevier Inc.

Cite

CITATION STYLE

APA

McCoy, K. D., Harris, N. L., Diener, P., Hatak, S., Odermatt, B., Hangartner, L., … Zinkernagel, R. M. (2006). Natural IgE production in the absence of MHC class II cognate help. Immunity, 24(3), 329–339. https://doi.org/10.1016/j.immuni.2006.01.013

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free