EP26 HIV infection masquerading as connective tissue disease

Abstract

We describe a case of 58 years old non-smoker lady, presented with acute onset livedo reticularis rash on lower limbs and background of sicca symptoms, oral ulcers, fatigue, paraesthesias in feet and arthralgias without any systemic or inflammatory joint symptoms. General examination showed livedo reticularis rash on both elbows and lower legs. There was no evidence of peripheral joint synovitis but she had nodal osteoarthritis in her hands. Systemic examination was unremarkable. Investigations revealed anaemia, pancytopenia, ESR of 77, low C4 and urine dipstick positive for leucocytes, nitrates, protein and blood. Schirmer's test, ANA and ENA screen was positive with positive RNP and equivocal SMdp antibody. She also had hypergammaglobulinaemia in a polyclonal pattern. This lady appeared to have mixed connective tissue disease and commenced on Hydroxychloroquine but stopped it shortly after developing floaters in her eye.She had poor response to Depomedrone injection. She had ongoing symptoms of fatigue, weight-loss, loose stools and abdominal pain, investigated further and CT scan showed hyperdense liver lesions and mesenteric lymphadenopathy. Oesophagogastroduodenoscopy showed oesophageal candidiasis. She was admitted with progressive symptoms. Further investigations showed a positive HIV test and liver biopsy came back positive for anaplastic lymphoma, Later she was diagnosed with advanced HIV disease, rapidly deteriorated with neutropenic sepsis and multi-organ failure and unfortunately died. Conclusion and learning points: There could be overlap of symptoms of connective tissue disease and viral infections e.g. HIV infection. Autoantibodies may be falsely positive in infections e.g. HIV and in malignancy. Risk factors of HIV infection should be considered during assessment of multisystem diseases like connective tissue diseases particularly prior to immunosuppression. Viral screening including HIV test should be considered in all high risk patients and particularly if the symptoms are atypical and do not quite fit well with the diagnosis.