From plants to humans, the ability to control infection at the level of an individual cell - a process termed cell-autonomous immunity - equates firmly with survival of the species. Recent work has begun to unravel this programmed cell-intrinsic response and the central roles played by IFN-inducible GTPases in defending the mammalian cell's interior against a diverse group of invading pathogens. These immune GTPases regulate vesicular traffic and protein complex assembly to stimulate oxidative, autophagic, membranolytic, and inflammasome-related antimicrobial activities within the cytosol, as well as on pathogen-containing vacuoles. Moreover, human genome-wide association studies and disease-related transcriptional profiling have linked mutations in the Immunity-Related GTPase M (IRGM) locus and altered expression of guanylate binding proteins (GBPs) with tuberculosis susceptibility and Crohn's colitis. © 2012 Elsevier Inc.
Kim, B. H., Shenoy, A. R., Kumar, P., Bradfield, C. J., & MacMicking, J. D. (2012, October 18). IFN-inducible GTPases in host cell defense. Cell Host and Microbe. https://doi.org/10.1016/j.chom.2012.09.007