The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori

Abstract

Background: Helicobacter pylori SabA outer membrane protein is crucial for the bacteria to adhere to host stomach surface during chronic infection. Results: The structure of the extracellular SabA adhesion region is determined by x-ray crystallography. Conclusion: SabA adhesion structure may provide insight into binding sites important for ligand receptor interactions. Significance: SabA is the first reported extracellular domain structure of the H. pylori outer membrane protein family. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.