Transformation and metastasis require cell invasion. In this issue of Developmental Cell, Caswell et al. describe a unique mechanism regulating tumor cell invasion. The authors report that an interaction between β1 integrin and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis, regulates the recycling of α5β1 integrin to the leading edge of cell pseudopodia. © 2007 Elsevier Inc. All rights reserved.
Weaver, V., & Werb, Z. (2007, October 9). G’rab’bing the Microenvironment for Invasion. Developmental Cell. https://doi.org/10.1016/j.devcel.2007.09.013