This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O2•− and NO• (29.62 and 52.48 μg/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123.51 and 134.29 μg/mL, respectively with no cytotoxic activity against normal MRC-5 cells. Gentisic, syringic and protocatechuic acids may be among the bioactive principles for the observed cytotoxicity. Taken all together, T. versicolor ethanol extract can be considered as a promising candidate for development of health promoting food supplement.
CITATION STYLE
Janjušević, L., Pejin, B., Kaišarević, S., Gorjanović, S., Pastor, F., Tešanović, K., & Karaman, M. (2018). Trametes versicolor ethanol extract, a promising candidate for health–promoting food supplement. Natural Product Research, 32(8), 963–967. https://doi.org/10.1080/14786419.2017.1366484
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