In Silico Destruction of Porphyromonas gingivalis Fimbriae by Streptomyces sp. Strain GMY02

Abstract

Porphyromonas gingivalis, a keystone pathogen in chronic periodontitis, has fimbria as one of the most important virulence factors because it plays a vital role in the pathogenesis of P. gingivalis infection. This bacterium has 2 fimbriae: the major (FimA) and minor (Mfa1) fimbriae. Fimbriae are attractive targets for anti-infective therapy for periodontal disease. The aim of this study was to analyze the interactions of several compounds thought to be present in Streptomyces sp. GMY02 strain against FimA and Mfa1 proteins in P. gingivalis fimbriae in silico. A total of 8 ligands were docked to FimA and Mfa1 fimbriae using AutoDock Vina in University of California, San Francisco (UCSF) Chimera 1.16. All of the selected ligands had higher free energy values than metronidazole as well. In conclusion, the compounds suspected to be present in Streptomyces sp. strain GMY02 has the potential to destruct P. gingivalis fimbriae.