Refining genetic stratification in T-ALL

Abstract

In this issue of Blood, Petit et al demonstrate the clinical utility of a genetic classifier combined with end of induction minimal residual disease (MRD) assessment and presenting white blood cell (WBC) count in the effective risk stratification of pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL).1 The integration of these factors allowed the identification of 3 discrete clinical risk groups providing an opportunity for improved treatment allocation.