Antimicrobial Profile of Pathogens Causing Community Acquired Urinary Tract Infection in Ain Shams University Hospitals

Abstract

Background: Community-acquired urinary tract infection (CA-UTI) is considered from the most common bacterial infections that is caused by wide range of Gram positive and Gram-negative bacteria. The increasing antimicrobial resistance and high recurrence rates of this infection threaten to increase the economic burden due to prolonged consumption of antibacterial agents. OBJECTIVE: Is to determine the susceptibility pattern of common pathogens causing CA-UTI in patients attending Ain Shams University Hospitals. Methodology: A total number of 385 midstream urine samples were collected from patients attending Ain Shams University Hospitals and subjected to conventional microbiological work up to isolate pathogens causing UTI. Antimicrobial susceptibility testing was done for isolates and the results were interpreted according to Clinical and Laboratory Standards Institute guidelines 2022. Results: From collected samples, 232 (60.3%) yielded significant growth, while 153 (39.7%) samples yielded insignificant or no growth after 48 hours incubation period. Most of isolated pathogens were retrieved from female patients (70.25%). The most common isolated pathogens were E. coli 105 (45.25%), followed by Klebsiella pneumoniae 45 (19.4%). Most isolates were susceptible to carbapenems and aminoglycosides. Least susceptibility was recorded to penicillin group. Conclusion: CA-UTI is more common in females and is mainly caused by E. coli and Klebsiella pneumoniae. Reporting pattern of Antimicrobial susceptibility of pathogens causing CA-UTI is crucial for better prescription of empirical treatment.