RNA–DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World

Citations of this article
Mendeley users who have this article in their library.
Get full text


The RNA world hypothesis posits that DNA and proteins were later inventions of early life, or the chemistry that gave rise to life. Most scenarios put forth for the emergence of DNA assume a clean separation of RNA and DNA polymer, and a smooth transition between RNA and DNA. However, based on the reality of “clutter” and lack of sophisticated separation/discrimination mechanisms in a protobiological (and/or prebiological) world, heterogeneous RNA–DNA backbone containing chimeric sequences could have been common—and have not been fully considered in models transitioning from an RNA world to an RNA–DNA world. Herein we show that there is a significant decrease in Watson–Crick duplex stability of the heterogeneous backbone chimeric duplexes that would impede base-pair mediated interactions (and functions). These results point to the difficulties for the transition from one homogeneous system (RNA) to another (RNA/DNA) in an RNA world with a heterogeneous mixture of ribo- and deoxyribonucleotides and sequences, while suggesting an alternative scenario of prebiological accumulation and co-evolution of homogeneous systems (RNA and DNA).




Gavette, J. V., Stoop, M., Hud, N. V., & Krishnamurthy, R. (2016). RNA–DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World. Angewandte Chemie - International Edition, 55(42), 13204–13209. https://doi.org/10.1002/anie.201607919

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free