UV spectrophotometric method for estimation of zileuton in pharmaceutical formulation

Abstract

A simple, rapid, sensitive and accurate UV-spectrophotometric method has been developed for the estimation of zileuton in pharmaceutical formulation. The method was developed by using 0.1 N Sodium hydroxide as a solvent and absorbance was measured at 230 nm. The drug exhibited the linearity in the concentration range of 1-6 μg/ml with correlation coefficient of 0.9993. The % recovery of the drug was found to be 98.62 % - 100.5 %. The method was validated as per ICH guidelines. The proposed methods are economical and sensitive for the estimation of zileuton in bulk and tablet dosage form.