High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)- acetyl]-2-cyano-(S)-pyrrolidine

Christian Oefner; Allan D'Arcy; Aengus Mac Sweeney; Sabine Pierau; Rana Gardiner; Glenn E. Dale

Journal Article

High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)- acetyl]-2-cyano-(S)-pyrrolidine

Acta Crystallographica - Section D Biological Crystallography (2003) 59(7) 1206-1212

DOI: 10.1107/S0907444903010059

104Citations

26Readers

Get full text

Abstract

The high-resolution structure of human DPP-IV as an apo enzyme and in complex with a cyano-pyrrolidine inhibitor is reported. The inhibitor forms a covalent intermediate with the active-site serine.

Cite

CITATION STYLE

APA

Oefner, C., D’Arcy, A., Mac Sweeney, A., Pierau, S., Gardiner, R., & Dale, G. E. (2003). High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)- acetyl]-2-cyano-(S)-pyrrolidine. Acta Crystallographica - Section D Biological Crystallography, 59(7), 1206–1212. https://doi.org/10.1107/S0907444903010059

High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)- acetyl]-2-cyano-(S)-pyrrolidine

Abstract

Cite

Register to see more suggestions