Effect of cyclosporin A on energy coupling in pea stem mitochondria

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Abstract

Effect of cyclosporin A on energy coupling in pea stem mitochondria is studied. It is found that incubation of mitochondria with 100 nM FCCP and/or CAtr, oligomycin, CaCl2, palmitate and ADP results, after some lag phase, in a collapse of Δ/ψ generated by succinate oxidation in the presence of rotenone. Cyclosporin A (0.2 - 0.8 nmol/mg mitochondrial protein) markedly increases the lag phase. The cyclosporin A effect requires dithioerythritol to be added to the isolation medium. Metabisulphite fails to substitute for dithioerythritol. The relationships between these effects and cyclosporin A-sensitive mitochondrial permeability transition in animal mitochondria are discussed. © 1995.

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Vianello, A., Macri, F., Braidot, E., & Mokhova, E. N. (1995). Effect of cyclosporin A on energy coupling in pea stem mitochondria. FEBS Letters, 371(3), 258–260. https://doi.org/10.1016/0014-5793(95)00897-I

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