Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain

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Abstract

Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling. © 2009 Federation of European Biochemical Societies.

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Yamashita, S., Yamashita, T., Yamada, K., & Tachibana, H. (2010). Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain. FEBS Letters, 584(4), 775–779. https://doi.org/10.1016/j.febslet.2009.12.044

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