Abstract
Tumor necrosis factor (TNF) is a critical mediator in the immune response to mycobacteria, particularly in the formation and maintenance of granulomas. Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mimetic peptide (TNF70-80) altered the number and cellular composition of granulomas. This change was associated with a moderate decrease in the bacterial burden.
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CITATION STYLE
Roach, D. R., Briscoe, H., Baumgart, K., Rathjen, D. A., & Britton, W. J. (1999). Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo. Infection and Immunity, 67(10), 5473–5476. https://doi.org/10.1128/iai.67.10.5473-5476.1999
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