Correlation between Arterial Stiffness with Left Ventricular Mass Index and Diastolic Function in Patients with Stage 3 and 4 of Non-Diabetic Chronic Kidney Disease

Abstract

Arterial stiffness (AS) is an independent predictive value of cardiovascular diseases. Patients that have chronic kidney disease have high mortality and morbidity of cardiovascular events. Increased AS is believed show cardiovascular damage. Therefore, this study was held to assess correlation of arterial stiffness to left ventricular mass index (LVMI) and diastolic function in stage 3 to 4 of non-diabetic CKD patients. This is a study using cross-sectional approach to 40 outpatients with stage 3 and 4 of CKD in Dr. Soetomo General Hospital Surabaya. Carotid ultrasound and β stiffness index formula was utilized to study carotid arterial stiffness (CAS) while echocardiography was used to assess diastolic function and LVMI. Patients that had severe heart valve disease, coronary artery disease, atrial fibrillation, congenital heart disease, history of diabetes mellitus, history of active smoking and cerebrovascular disease were not included in this study. There is significant relation between CAS with E/E' (r=0.517, p=0.001) and LVMI (r=0.396, p=0.011), also between SBP with LVMI (r=0.491, p=0.001). SBP has more significant role for LVMI (p<0.001) than CAS. Arterial stiffness had significant positive relation with E/E' and LVMI in patient with stage 3 and 4 of non-diabetic chronic kidney disease.