New bicyclic taxane diterpenoids from Taxus sumatrana

Abstract

Investigation of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of two new bicyclic taxoids, tasumatrols M (1), and N (2) and a new baccatin III derivative, tasumatrol O (3) together with the previous known 7-deacetylcanadensene (4) and 2α,7β, 13α-triacetoxy-5α,9α-dihydroxy-2(3→20) abeotaxa-4(20),11-dien-10-one. The structures of these taxanes were established on the basis of spectroscopic analyses, especially 1- and 2D NMR, and chemical derivatization. © 2005 Pharmaceutical Society of Japan.