Effect of Soybean, Virgin Coconut and Moringa oleifera Seed Oils on the Propylthiouracil Induced Hypothyroidism in Rats

Abstract

This study investigated the possible effect of soybean, virgin coconut and Moringa oleifera seed oils for 8 weeks on Propylthiouracil (PTU) induced hypothyroidism in rats. Thirty five male albino rats were divided into two main groups; Group (I) (7 rats) was fed only basal diet and served as a negative control group. Group (II) (28 rat) were injected with (10 mg / kg / day PTU) for 15 day to cause hypothyroidism, then divided into 4 subgroups: namely control positive group based on basal diet, and 2nd, 3rd and 4th subgroup were treated orally with dose of 5ml/kg BW oils of Soybean (SO), Virgin coconut (VCO) and M.oleifera seeds (MOO), respectively beside basal diet. The results showed that PTU exposed rats showed significant decrease (P≤0.05) in serum FT3, FT4 levels and significant increase (P≤0.05) in serum TSH levels. The orall treatement with SO, VCO and MOO was significantly increased FT4 and FT3, while decreased the level of TSH comparing with the positive control group. It was also reduced level of malondialdehyde (MDA) level, significantly, increased activity of liver antioxidant enzymes-superoxide dismutase (SOD) and improved liver functions and lipid profile compared with the positive control group. So, it could be concluded that oils of soybean, virgin coconut and M. oleifera seed oils improve the role of thyroid by raising thyroid hormones and reducing oxidative stress in patients with hypothyroidism. [ABSTRACT FROM AUTHOR]