Neuroprotective Effect of Garcinia Mangostana on Streptozotocin Induced Sporadic Type Alzheimer’s Disease in Mice

Abstract

Objectives: The main objective of the study is to determine the neuroprotective potential of ethonolic extract of Garcinia mangostana (EEGM) in mouse against Intracerebroventricular- Streptozotocin (ICV –STZ) induced sporadic type Alzheimer's disease. Methods: Neurotoxicity was induced by ICV injection of STZ (0.5 mg/kg/b.w) as a first dose then the second dose after the 48 hours and the animals were pre-treated with ethanolic extract of Garcinia mangostana for 28 days. To assess the behavioral parameters learning and memory, open field and Y-maze were employed. Acetylcholinesterase, antioxidant enzymes (superoxide dismutase, glutathione peroxidise, reduced glutathione and catalase) were estimated in brain tissue. Results: Pre-treatment with EEGM (200 and 400 mg/kg/b.w) exhibited a dose dependent reduction of AChE levels and increased habituation memory and percentage alteration which are indicative of the enhanced cognitive function. The extract showed significant increase in the antioxidant parameter. Conclusion: The study results suggested that the neuroprotective potentiality of EEGM against ICV STZ induced neurotoxicity. The extract of EEGM proved to have a potential therapeutic action in preventing or decreasing the progression of sporadic Alzheimer‟s disease due to aging and oxidative stress.