Obesity is a modifier of automatic cardiac responses to fine metal particulates

Abstract

Background: Increasing evidence suggests that obesity may impart greater susceptibility to adverse effects of air pollution. Particulate matter, especially PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm), is associated with increased cardiac events and reduction of heart rate variability (HRV). Objectives: Our goal was to investigate wether particle-mediated autonomic modulation is aggravated in obese individuals. Methods: We examined PM2.5 mediated acute effects on HRV and heart rate (HR) using 10 24-hr and 13 48-hr ambulatory electrocardiogram recordings collected from 18 boilermakers (39.5 ± 9.1 years of age) exposed to high levels of metal particulates. Averages HR and 5-min HRV [SDNN: standard deviation of normal-to-normal intervals (NN): sMSSD: square-root of mean squared-differences of successive NN intervals; HF: high frequency power 0.15-0.4 Hz] and personal PM2.5 exposures were continuously monitored. Subjects with body mass index ≥ 30 kg/m2 were classified as obese. Mixed-effect models were used for statistical analyses. Results: Half (50%) of the study subjects were obese. After adjustments for confounders, each 1-mg/m3 increase in 4-hr moving average PM2.5 was associated with HR increases of 5.9 bpm [95% confidence interval (CI), 4.2 to 7.7] and with 5-min HRV reduction by 6.5% (95% CI, 1.9 to 11.3% for SDNN, 1.7% (95% CI, - 4.9 to 8.44%) for rMSSD, and 8.8% (95% CI,-3.8 to 21.3%) for HF. Obese individuals, and had more PM2.5-mediated HRV reductions (2-to3-fold differences) than nonobese individuals had greater PM2.5-mediated HR increases (9-bpm vs. 4bpm increase in HR for each 1-mg-/m3 increase in PM2.5: P, 0.001). Conclusions: Our study reveeled greater autonomic cardiac responses to metal particulates in obese workers, supporting the hypothesis that obesity may impart greater susceptibility to acute cardiovascular effects of fine particles.