Cocaine-induced myocardial injury identified as multiple mid-wall foci of enhancement by contrast-enhanced cardiac MRI and large troponin rise

Abstract

A 26-year-old man with no relevant medical history was admitted with severe retrosternal chest pain. There were no associated (Figure Presented) symptoms, and no relationship of the pain to inspiration, exertion or posture. It transpired that he infrequently inhaled heroin and cocaine, and also used oral ecstasy tablets, the latter two substances 3 days prior to presentation. He also smoked at least a pack of cigarettes per day. Results of initial cardiac enzyme tests revealed a creatine kinase level of 710 U/L (normal range 40 - 300 U/L) and troponin I of 10.3 μg/L (normal range < 0.14 μg/L) which rapidly returned to baseline after the resolution of his pain. 12-lead electrocardiogram showed sinus rhythm with right ventricular conduction delay. Biphasic T-waves were present infero-laterally, suggestive of myocardial ischaemia. Computed tomography of the coronary and pulmonary arteries was unremarkable. Cardiac magnetic resonance imaging (CMRI) was performed and demonstrated normal left ventricular function with no evidence of regional wall motion abnormality and an ejection fraction of 55%. However, there were multiple foci of mid-wall and subepicardial late enhancement (LE) in the apical septum and apical lateral wall (figure 1). There was no pericardial effusion. There are multiple potential causes of myocardial injury in conjunction with cocaine use. The character and temporal pattern of the pain in conjunction with sharp rise of troponin, and multiple mid-wall foci of late enhancement on CMRI is suggestive of infarction related to cocaine-induced vasoconstriction of coronary arterioles which may have been exacerbated by concomitant increase in platelet aggregation and adrenergic drive. Although alternative diagnoses of myocarditis, or more chronic conditions such as sarcoidosis, arrhythmogenic right ventricular dysplasia, or cardiomyopathy were considered in light of the LE, this was less consistent with the presentation.