Abstract
We review the evidence for altered gene expression in Alzheimer's disease brain and identify alternative molecular approaches for isolating additional novel markers. One marker, pADHC-9, was isolated from a human hippocampal cDNA library by differential screening with AD and control cDNA probes. This clone hybridizes to a 2 Kb RNA which is increased 2 fold in AD hippocampus. The deduced amino acid sequence of pADHC-9 codes for a 52 kDAL protein similar to a testicular sulfated glycoprotein secreted by rat Sertoli cells. The normal function of this protein in brain and whether that function is altered in Alzheimer's disease is unknown. © 1989, Canadian Neurological Sciences Federation. All rights reserved.
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CITATION STYLE
May, P. C., Johnson, S. A., Poirier, J., Lampert-Etchells, M., & Finch, C. E. (1989). Altered Gene Expression in Alzheimer’s Disease Brain Tissue. Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques, 16(S4), 473–476. https://doi.org/10.1017/S0317167100029796
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