Abyssomicins from the South China Sea deep-sea sediment verrucosispora sp.: Natural thioether michael addition adducts as antitubercular prodrugs

Abstract

From the deep: The title actinomycete yielded three new abyssomicins J-L. The dimeric thioether J (see scheme) represents a unique example of a masked Michael acceptor with anti-TB properties. Mechanistic insights into the biosynthesis, biomimetic synthesis, stability, and biological mechanism of action of abyssomicins aid our understanding of, and prospects for the development of Michael-acceptor-based drugs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.