The flow through cell methodology in the evaluation of intralumenal drug release characteristics

Abstract

In this paper the usefulness of the flow through cell apparatus in the evaluation of intralumenal drug release characteristics is reviewed. Initially,the basic characteristics of this setup are presented.Then,the relative advantages and disadvantages of the flow through cell apparatus over other in vitro release setups are summarized. Finally,potential applications of this setup are discussed according to the solubility characteristics of the tested compound and the release characteristics of the dosage form.