The programmed cell death (PCD) of neurons is generally thought to be cell autonomous and not to require a death signal from other cells. A recent study by Marin-Teva et al., in this issue of Neuron, brings this theory into question and suggests that neighboring microglia actively participate in the PCD of Purkinje cells in the cerebellum.
Taylor, A. R., & Oppenheim, R. W. (2004, February 19). The Kiss of Death. Neuron. Cell Press. https://doi.org/10.1016/S0896-6273(04)00079-0