[P2–493]: COMPARISONS OF ETIOLOGIES, CLINICAL FEATURES FOCUSING ON BEHAVIOR PROBLEMS AND CAREGIVER BURDENS BETWEEN EARLY‐ONSET DEMENTIA (EOD) AND LATE‐ONSET DEMENTIA (LOD)

Abstract

Background: Although EOD and LOD have common etiologic disease, they may show the different clinical features including cognition and abnormal behavior. The burden of their caregivers could be also different according to onset age. The aims of this study are to explore the differences of etiology, behavioral features and burdens of their caregivers between EOD and LOD. Methods: We enrolled 1341 clinically demented patients who satisfied working inclusion criteria from 31 dementia centers nationwide in Korea. 200 EOD (age; 58.3 + 5.8, 76 male, education; 10.3 + 3.4 years, MMSE; 20.9 + 4.9) and 1133 LOD (age; 76.5 + 5.7, 394 male, education; 5.4 + 3.8, MMSE; 18.7 + 5.3) patients were evaluated using an electronic case report form which include information about demographic findings, probable etiologic disease, general cognitive status, neuropsychiatric inventory (NPI) and caregiver burden. Their cognitive tests, NPI and the assessment of caregiver burden were followed after 3 months and 6 months. Results: The most frequent etiologic disease in both group was Alzheimer's disease (63.5% in EOD and 63.3% in LOD). Multi-infarct dementia was more popular in LOD, but Frontotemporal dementia in EOD. Among the items of NPI, delusion, hallucination and abberant motor behavior were more frequent in LOD (p<0.01). Despite of rarer prevalence, caregiver of EOD patients had greater stress for delusion, abberant motor behavior and abnormal sleep behavior than LOD. The MMSE score was negatively correlated with the frequency and severity of NPI and caregiver burden (p<0.001). Conclusions: We suggest that future study including EOD has to be differently approached to LOD in aspect of patients and caregiver. It should be warranted to establish the recommendation for caregiver of EOD patients who have been overlooked.