Association between Takayasu arteritis and ulcerative colitis - case report and review of serological HLA analysis

Abstract

Background: Takayasu arteritis and ulcerative colitis are immune-mediated infammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported. Case Report: In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9. Conclusions: We present a case report and review of the pertinent literature on serological analysis of HLA hap-lotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation. © Med Sci Monit, 2011.