Using the BITOLA system to identify candidate genes for Parkinson's disease

Abstract

Complexity of multifactorial diseases as Parkinson's disease (PD) often complicate identifying causal genetic factors by traditional approaches such as positional cloning and candidate gene analyses. PD is etiologically and genetically complex disease and second most common neuro degenerative disorder after Alzheimer's disease. T e most cases of PD are idiopathic and small growing subset of individuals have single gene defect as the cause. T e main goal of this research was to identify the potential candidate genes for idiopathic PD by using biomedical discovery support system (BITOLA). For detecting the potential candidate genes for PD was used opened system of bioinformatics tool BITOLA. Data of chromosome location, tissue specific expression of potential candidate genes and their potential association with PD were obtained from Medline, Locus Link, Gene Cards and OMIM. By using BITOLA systemis identified 17 genes as potential candidate genes for PD. T e role of three genes (MAPT, PARK2, UCHLi) in PD were confirmed earlier. Discovering the novel candidate genes for multifactiorial diseases by using specially mentioned bioinformatics tool BITOLA could offer the new opportunity for researching genetics base of PD without using tissue samples of patients. © 2011 Association of Basic Medical Sciences of FBIH. All rights reserved.