Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: The Cardiometabolic Risk in Chinese (CRC) study

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Abstract

Objectives: Recent studies have associated neck circumference (NC) with insulin resistance (IR). We examined whether such relation was modified by other metabolic risk factors. Methods: The study samples were from a community-based health examination survey in central China. A total of 2588 apparently healthy Chinese men and women were included. Results: Plasma levels of total cholesterol (TC), HDL-C, uric acid (UA) and diastolic blood pressure (DBP) were independently associated with NC after adjusted for age, sex, body mass index (BMI), waist circumference (WC) and hip circumference (HC) (P = 0.009, 0.001, 0.015 and 0.015, respectively). We observed significant interactions of NC with triglyceride (TG) and UA (all the p for interaction = 0.001) in relation to HOMA-IR. It appeared that the associations between NC and HOMA-IR were more evident in those with higher UA or TG level. Conclusions: Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.

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Liang, J., Teng, F., Liu, X., Zou, C., Wang, Y., Dou, L., … Qi, L. (2014). Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: The Cardiometabolic Risk in Chinese (CRC) study. Diabetology and Metabolic Syndrome, 6(1). https://doi.org/10.1186/1758-5996-6-116

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