Mesoporous particles for transdermal delivery of the antifungal drug griseofulvin

Abstract

Griseofulvin is an antifungal antibiotic applying for the treatment of dermatophyte infections. The most common delivery route of this drug is oral. The dosage of griseofulvin varies depending on whether the drug is administered as a microsized or an ultramicrosized preparation. In order to avoid possible incidental systemic toxicity associated with the oral delivery route and reduce the therapeutic dose, a novel approach for the griseofulvin administration is proposed. Immobilization of the drug into mesoporous calcium carbonate particles together with their further ultrasonically-assisted topical application provides the efficient transdermal transportation. Accumulation of griseofulvin-loaded carriers inside hair follicles of the rat is demonstrated in vivo, allowing by this means the targeted delivery of the antifungal drug to the lesion area of skin. No significant toxicity of the system is shown for rat and human fibroblasts cells in vitro.