Evaluation of the bioactive potentialities of a diacetaldehyde terpenoid isolated from Curcuma caesia Roxb.

Abstract

This paper represents evaluation of the bioactive potentialities of a diacetaldehyde terpenoid isolated from Curcuma caesia Roxb. The terpenoid was identified as (2Z,2'Z)-2,2'- (3aR,10aS)- 1,3,5,8,9,9- hexamethyl- 1,2,3,3a-tetrahydrobenzo [f] azulene- 4,10 (5H,8H,9H,10aH) - diylidene) diacetaldehyde. Assessment of its antitumour activity, antifungal activity and antibacterial activity was performed using brine shrimp cytotoxicity assay, agar cup method and disc diffusion assay respectively. The antitumour, antifungal as well as antibacterial activity was promising and it showed 25 mg/ml (LC 50 value), (25 mg/ml, 67 mg/ml, 39 mg/ml), (235 µg/ml, 257 µg/ml, 210 µg/ml, 322 µg/ml) value respectively. This study represents the first report of bioactive nature of (2Z,2'Z)-2,2'- (3aR,10aS)- 1,3,5,8,9,9- hexamethyl-1,2,3,3atetrahydrobenzo [f] azulene- 4,10 (5H,8H,9H,10aH)- diylidene) diacetaldehyde isolated from plants.