Serum ionized calcium and corrected total calcium in borderline hyperparathyroidism

Abstract

25 borderline-hyperparathyroidism patients whose total serum calcium concentration was within normal limits (reference range: 2.25-2.75 mmol/liter) but whose concentrations of serum ionized calcium were above normal (reference range: 1.03-1.23 mmol/liter). Their hyperparathyroidism was histopathologically verified. To compare the discriminating value of corrected serum calcium with ionized calcium, we studied the serum calcium and albumin concentrations in a reference group of 2098 patients. After patients from endocrine and dialysis departments were excluded from the reference group, we obtained the range (mean ± 2 SD) 2.05-2.71 mmol/liter for uncorrected serum calcium and 2.11-2.63 mmol/liter for corrected serum calcium. The correction factor for calcium on albumin was 20 μmol/g. Even with this limit for corrected serum calcium, 13 of 25 borderline hyperparathyroidism patients had values that fell within the reference range. It is concluded that correcting total serum calcium values for serum albumin concentration improves discrimination of borderline hyperparathyroid patients, but that measurement of ionized calcium in serum discriminates better.