Activity of some actinomycetes and high plants against foot and mouth disease virus

Abstract

Actinomycete cultures extracts and leaves extracts of high plants were tested in vivo against foot and mouth disease virus. A virus strain “O” adapted to mice muscle and twenty-one-day-old 10∼13 g male mice as laboratory animals were used. From the experimental results the survival index was obtained. Out of 63 assayed Actinomycete strains five were active, as regard plants 3 out of 36 were active. Various inoculation schemes were assayed. A single dose of extracts administered 24 hours before infection produced a significant survival index from which it is possible to infer the existance of an indirect viral inhibitory mechanism. Also it was proved that there is no inhibitor that acts in vitro in treated animals serum. It has not yet been possible to obtain a purified active substance from the extracts and also it was observed that the extracts loose gradually their activity. © 1972, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.