Optogenetics has emerged in the past decade as a technique to modulate brain activity with cell-type specificity and with high temporal resolution. Among the challenges associated with this technique is the difficulty to target a spatially restricted neuron population. Indeed, light absorption and scattering in biological tissues make it difficult to illuminate a minute volume, especially in the deep brain, without the use of optical fibers to guide light. This work describes the design and the in vivo application of a side-firing optical fiber adequate for delivering light to specific regions within a brain subcortical structure.
CITATION STYLE
Castonguay, A., Thomas, S., Lesage, F., & Casanova, C. (2016). Optogenetic tools for confined stimulation in deep brain structures. In Methods in Molecular Biology (Vol. 1408, pp. 267–279). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3512-3_18
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