Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

51Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.
Get full text

Abstract

A quinine-derived thiourea catalysed the enantioselective addition of 4-substituted pyrazolones to isatin-derived ketimines, providing a variety of aminooxindole-pyrazolone adducts containing congested vicinal tetrasubstituted stereocentres with excellent outcomes (up to 98% yield, >20:1 dr and 98% ee). (Figure presented.).

Cite

CITATION STYLE

APA

Amr, F. I., Vila, C., Blay, G., Muñoz, M. C., & Pedro, J. R. (2016). Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters. Advanced Synthesis and Catalysis, 358(10), 1583–1588. https://doi.org/10.1002/adsc.201600036

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free