Early detection of microcirculatory impairment in diabetic patients with foot at risk

Abstract

OBJECTIVE - To assess microcirculatory impairment and alterations of the skin oxygen supply in diabetic patients with foot at risk. RESEARCH DESIGN AND METHODS - This study evaluated skin blood flow in 21 type 2 diabetic patients with a foot at risk (defined as a foot with neuropathy but without ulceration or previous ulcerations), 20 type 2 diabetic patients without foot lesions or neuropathy, and 21 normal subjects as a control group. The skin blood flow was determined by measuring the transcutaneous oxygen pressure (TcPo2) at the dorsum of the foot in supine and sitting position. The clinical assessment included standard measures of peripheral and autonomic neuropathy, but peripheral vascular disease was excluded by Doppler ultrasound. RESULTS - In supine position, TcPo2 was significantly reduced (means ± SE) in diabetic patients with foot at risk (6.04 ± 0.52 kPa) compared with diabetic (7.14 ± 0.43 kPa, P = 0.035) and nondiabetic (8.10 ± 0.44 kPa, P = 0.01) control subjects. The sitting/supine TcPo2 difference was higher in diabetic subjects with foot at risk (3.13 ± 0.27 kPa) compared with both diabetic (2.00 ± 0.18, P = 0.004) and nondiabetic (1.77 ± 0.15 kPa, P = 0.0003) control subjects. The mean sitting/supine ratio was 1.70 ± 0.12 in diabetic patients with foot at risk, 1.32 ± 0.04 in diabetic control subjects, and 1.25 ± 0.03 in nondiabetic control subjects (P = 0.007). The sitting/supine TcPo2 ratio was negatively correlated with the heart rate variation coefficient at rest (r = -0.32, P = 0.044) and at deep respiration (r = -0.31, P = 0.046). CONCLUSIONS - Our data indicate that skin oxygen supply is reduced in type 2 diabetic patients with foot at risk. This is probably due to an impaired neurogenic blood flow regulation and may contribute to capillary hypertension, followed by disturbed endothelial function leading to edema and skin damage of the foot. The determination of TcPo2 appears to be a useful tool in screening type 2 diabetic patients for foot at risk.