Tumor suppression by p53 without apoptosis and senescence: Conundrum or rapalog-like gerosuppression?

Abstract

I discuss a very obscure activity of p53, namely suppression of senescence (gerosuppression), which is alsomanifested as anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects of p53. But cangerossuppression suppress tumors? © Blagosklonny.